Evaluate the severity of bone impairment in different types of sickle cell anemia in Basrah province- Iraq

Sickle cell anemia (SCD) is one of the important health problems in Basrah, southern Iraq. which probably most common known hereditary blood disorder. patients with sickle disorders often suffer from chronic hemolytic anemia, causes bone marrow hyperplasia too. The present study aimed to evaluate severity impairment different types patients. Patients SCA (n=120) 60 males and females were on follow up Basra center for Hereditary Blood Disease, who included this age sex matched healthy persons (n=60) as controls. biomarkers had role many biological processes. measure serum levels such as; BCTx, BSAP, CRP, DPD, IGF-1, OT, TRACP-5b, FER, IGFBPT, Intact (iPTH), Ostase, PINP Ca+. Using Kruskal-Wallis test statistical test, markers control groups. results showed significant differences among groups group all that measured (P=0.0001). Conclusion: compound heterozygous(Hb SC Hb S/β-thal, ) are less severe than homozygous genotype (HbSS).